The 2012 Nobel Prize-winning discovery that changed regenerative medicine forever. Understanding why our exosome source makes all the difference.
Awarded to Shinya Yamanaka and John B. Gurdon for the discovery that mature, specialised cells can be reprogrammed to become pluripotent — the foundational science behind iPSC technology and our exosome source.
Every cell in your body — whether a skin cell, liver cell, or neuron — contains the same complete DNA. What makes each cell type different is which genes are switched on. In 2006, Yamanaka discovered that by introducing just four transcription factors (now called Yamanaka factors: Oct4, Sox2, Klf4, c-Myc), any adult specialised cell could be reprogrammed back to a pluripotent state — essentially becoming a stem cell again.
These reprogrammed cells are called Induced Pluripotent Stem Cells (iPSC). From this pluripotent state, they can theoretically become any cell type in the body — and critically, they secrete exosomes carrying the biological signature of youth and unlimited regenerative potential.
Adult specialised cells are reprogrammed using Yamanaka factors back to a pluripotent ground state.
iPSC cells regain the biological youth and unlimited differentiation potential of embryonic stem cells.
iPSC cultures secrete exosomes richly loaded with pluripotent regenerative signals — the most potent available.
Exosomes are purified and concentrated in our GMP-certified partner facility in Taipei, Taiwan.
Our iPSC exosomes are produced by a leading biotechnology research university in Taipei, Taiwan — a globally recognised centre of stem cell science excellence. The facility operates under Good Manufacturing Practice (GMP) standards, the highest pharmaceutical manufacturing standard globally.
Every batch is tested for: particle size distribution (NTA), protein marker expression (CD9, CD63, CD81), sterility, mycoplasma, endotoxin levels, and particle concentration before release. Full certificate of analysis available for clinic partners.
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